DIANA TOOLS - MicroT-CDS

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Results: 2 targets of miRNAs hsa-let-7a-5p

found in genes ENSG00000134323

and ENSG00000167081

and in genes related to KEGG pathways with description that matches 'cancer'. Threshold is set to 0.7.

Name:	hsa-let-7a-5p
Alternative description:	MIMAT0000062
Related names:
miRNA sequence:	ugagguaguagguuguauaguu
External links:	miRBase
DIANA resources:	microT-CDS
Related diseases:	Acute Disease Adenocarcinoma Adenoma Adenoma, Bile Duct Alzheimer Disease Anemia, Sickle Cell Aortic Valve Stenosis Ascariasis Asthma Autoimmune Diseases Azoospermia Bites and Stings Bone Neoplasms Brain Neoplasms Breast Neoplasms Breast Neoplasms, Male Burkitt Lymphoma Carcinoma Carcinoma, Hepatocellular Carcinoma, Non-Small-Cell Lung Carcinoma, Papillary Carcinoma, Renal Cell Carcinoma, Small Cell Carcinoma, Squamous Cell Cardiomyopathies Cardiomyopathy, Hypertrophic Cell Transformation, Neoplastic Chromosome Aberrations Chromosome Deletion Chronic Periodontitis Colitis, Ulcerative Colonic Neoplasms Colorectal Neoplasms Cystadenocarcinoma, Serous Dermatitis, Atopic Diabetes Mellitus Diabetes Mellitus, Type 2 Disease Disease Models, Animal Disease Progression Disorders of Sex Development Down Syndrome Echinococcosis Esophageal Neoplasms Facial Neoplasms Fatty Liver Fibrosis Genetic Predisposition to Disease Glioma Head and Neck Neoplasms Hematologic Neoplasms Hepatitis C, Chronic HIV Infections Hodgkin Disease Huntington Disease Hypertension Inflammation Influenza in Birds Insulin Resistance Intellectual Disability Ischemia Kidney Failure, Chronic Kidney Neoplasms Laryngeal Neoplasms Leiomyoma Leprosy Leukemia Leukemia, Lymphocytic, Chronic, B-Cell Leukemia, Myeloid, Acute Leukemia, Promyelocytic, Acute Liver Cirrhosis Liver Neoplasms Lung Neoplasms Lupus Erythematosus, Systemic Lupus Nephritis Lymphatic Metastasis Lymphoma, Follicular Lymphoma, Large B-Cell, Diffuse Malaria, Falciparum Marek Disease Melanoma Mesothelioma Mouth Neoplasms Multiple Myeloma Multiple Sclerosis Muscular Dystrophies Myocardial Infarction Myocardial Reperfusion Injury Myotonic Dystrophy Nasopharyngeal Neoplasms Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Recurrence, Local Neoplasms Neoplasms, Experimental Neoplasms, Glandular and Epithelial Nerve Degeneration Nerve Sheath Neoplasms Neuralgia Neuroblastoma Obesity Ovarian Neoplasms Pancreatic Neoplasms Pituitary Neoplasms Poultry Diseases Precursor Cell Lymphoblastic Leukemia-Lymphoma Prostatic Neoplasms Psoriasis Pulmonary Embolism Retinoblastoma Schistosomiasis japonica Scrapie Sepsis Skin Neoplasms Small Cell Lung Carcinoma Stomach Neoplasms Stroke Thyroid Neoplasms Translocation, Genetic Trichuriasis Tuberculosis Urinary Bladder Neoplasms Uterine Cervical Neoplasms Uterine Neoplasms Uveal Neoplasms

Gene ID:	MYCN
Expression:	ovary,lymph node,prefrontal cortex,H1-hESC,stomach,kidney,frontal lobe,temporal lobe,cerebral cortex,adrenal gland,brain,animal ovary,lung,thyroid,small intestine,testis,placenta,bladder,duodenum
External Gene ID:	ENSG00000134323
Description:
Chromosome:	2
DIANA resources:	microT v4 microT-CDS

Gene ID:	PBX3
Expression:	lymph node,prefrontal cortex,H1-hESC,breast,appendix,HUVEC cell line,HSMM cell line,liver,salivary gland,temporal lobe,HMEC cell line,gall bladder,K562,IMR-90,MCF-7,adrenal gland,brain,HepG2,BJ,small intestine,HeLa-S3,colon,esophagus,placenta,NHLF cell line,A549,adrenal,SK-N-SH_RA,leukocyte,adipose tissue,cerebellum,ovary,SK-N-SH,stomach,bone marrow,kidney,pancreas,frontal lobe,cerebral cortex,GM12878,skin,skeletal muscle,NHEK cell line,heart,animal ovary,prostate,lung,thyroid,CD20-positive B ce
External Gene ID:	ENSG00000167081
Description:
Chromosome:	9
DIANA resources:	microT v4 microT-CDS

Ensembl Gene Id

miRNA name

miTG score

Also Predicted

ENSG00000167081 (PBX3)

hsa-let-7a-5p

0.996115154960663

Gene details
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miRNA details
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pubMed links: miRNA | gene | both
UCSC graphic

Region

Binding Type

Transcript position

Score

Conservation

UTR3

6mer

108-128

0.0111191847722645

Position on chromosome:

9:128728175-128728195

Conserved species:

panTro2,rheMac2,rn4,mm9,oryCun2,bosTau4,canFam2,dasNov2,loxAfr3,echTel1,monDom5,galGal3,xenTro2,tetNig2,fr2

Binding area:

(Transcript)	5'	GCCCAGG__G______C__GGA______U	3'
		_______AA_UGUGCA_UC___UACCUC_
		_______\|\|_\|.\|.\|\|_.\|___\|\|\|\|\|\|_
		_______UU_AUAUGU_GG___AUGGAG_
(miRNA)	3'	_________G______U__AUG______U	5'

UTR3

6mer

469-490

0.0054005777043383

Position on chromosome:

9:128728536-128728557

Conserved species:

panTro2,rheMac2,bosTau4,canFam2,loxAfr3,echTel1,monDom5,galGal3

Binding area:

(Transcript)	5'	GUAAAAA_______AUAC___AA______	3'
		_______GUACAAU____ACU__ACCUCA
		_______.\|\|\|\|\|.____\|\|\|__\|\|\|\|\|\|
		_______UAUGUUG____UGA__UGGAGU
(miRNA)	3'	______A_______GA_____________	5'

UTR3

6mer

499-521

0.00301587724045049

Position on chromosome:

9:128728566-128728588

Conserved species:

panTro2,rheMac2,canFam2

Binding area:

(Transcript)	5'	CGUUAA___AG______AA____C______	3'
		______AGC__AUGCAA___AUU_ACCUCA
		______\|.\|__\|\|.\|\|\|___\|.\|_\|\|\|\|\|\|
		______UUG__UAUGUU___UGA_UGGAGU
(miRNA)	3'	_________A_______GGA__________	5'

UTR3

7mer

971-987

0.0317078388899661

Position on chromosome:

9:128729038-128729054

Conserved species:

panTro2,rheMac2,rn4,mm9,oryCun2,bosTau4,canFam2,loxAfr3,echTel1,monDom5,galGal3,xenTro2

Binding area:

(Transcript)	5'	ACCAAUCAAAAC_____U___________	3'
		____________ACAGC_UUAUUACCUCA
		____________\|\|\|.\|_.\|\|.\|\|\|\|\|\|\|
		____________UGUUG_GAUGAUGGAGU
(miRNA)	3'	___________A_________________	5'

UTR3

8mer

1029-1054

0.0501185897692395

Position on chromosome:

9:128729096-128729121

Conserved species:

panTro2,rheMac2,rn4,mm9,oryCun2,bosTau4,canFam2,dasNov2,loxAfr3,echTel1,monDom5,galGal3,xenTro2,tetNig2,fr2

Binding area:

(Transcript)	5'	GU____UAGA____UC____________U	3'
		__AGCU____GUGC__ACUUACUACCUC_
		__\|.\|\|____.\|.\|__\|\|.\|\|\|\|\|\|\|\|\|_
		__UUGA____UAUG__UGGAUGAUGGAG_
(miRNA)	3'	______________U_____________U	5'

ENSG00000134323 (MYCN)

hsa-let-7a-5p

0.994181524143106

Gene details
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miRNA details
	loading...

pubMed links: miRNA | gene | both
UCSC graphic

Region

Binding Type

Transcript position

Score

Conservation

UTR3

6mer

197-220

0.001967087653312

Position on chromosome:

2:16086417-16086440

Conserved species:

panTro2,rheMac2,loxAfr3

Binding area:

(Transcript)	5'	UGGGU___CC________C__CC______	3'
		_____GGC__UGCAGCCU_CU__ACCUCA
		_____..\|__\|.\|\|.\|\|\|_\|\|__\|\|\|\|\|\|
		_____UUG__AUGUUGGA_GA__UGGAGU
(miRNA)	3'	________AU________U__________	5'

UTR3

7mer

495-511

0.0360254268728252

Position on chromosome:

2:16086715-16086731

Conserved species:

panTro2,rheMac2,rn4,mm9,oryCun2,bosTau4,canFam2,dasNov2,loxAfr3,echTel1,galGal3,xenTro2

Binding area:

(Transcript)	5'	UCAUACCUAAGU______A______A_______	3'
		____________ACUGUA_____UA_UACCUCA
		____________\|\|\|.\|\|_____\|\|_\|\|\|\|\|\|\|
		____________UGAUAU_____AU_AUGGAGU
(miRNA)	3'	___________U______GUUGG__G_______	5'

UTR3

7mer

852-875

0.0567355722029997

Position on chromosome:

2:16087072-16087095

Conserved species:

panTro2,rheMac2,rn4,mm9,oryCun2,bosTau4,canFam2,loxAfr3,echTel1,galGal3,xenTro2,tetNig2,fr2,danRer6

Binding area:

(Transcript)	5'	UGCAU_________A__UUGAAA_______	3'
		_____CU_UAUAGC_CU______UACCUCA
		_____\|\|_\|\|.\|.\|_\|\|______\|\|\|\|\|\|\|
		_____GA_AUGUUG_GA______AUGGAGU
(miRNA)	3'	____U__U_________UG___________	5'